RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potent anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeabilityIn VitroRIP1/RIP3/MLKL activator 1 (Compound 6i) (96 h) shows antiproliferative activities